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Clindamycin Clinical Pharmacology-It Works!
| November 7, 2011 | Posted by admin under Clinical Pharmacology |
The clindamycin is a lincosamide antibiotics and it has been approved by FDA. It is meant to treat streptococcal, anaerobic or staphylococcal infection. The most concern of this medicine is to cause diarrhea especially the clostridium difficile colitis. According to the clindamycin Clinical Pharmacology, the drug has to be used because of it’s intracellular levels of phagocytic cells and high levels in bones. Sometimes, it is believed that it has antitoxin effect which works against toxin of staphylococci and streptococci.
The clindamycin Clinical Pharmacology should be about it’s activity spectrum, pharmacology and adverse effects. The clindamycin normally works by binding the ribosomal subunit of bacteria. It disrupts the protein synthetis since it interferes with transpeptidation reaction and at it’s return it will inhibit the chain elongation. Macrolides such as erythromycin or cholamphenicol works in the same way and they can compete for the binding when they are used together. The medicine can be discussed together with the macrolides but in the reality, they are not and they do not have chemical relationship.
Clindamycin can increase the phagocytosis and opsonization of the bacteria and even subinhibitory concentration. When the drug disrupts the bacterial protein synthesis, the causes of the bacteria changes in the cells wall surface will also decrease. The drug also can exert and extend postantibiotic effects against different strains of bacteria. This can be because of the persistence of the drug on its ribosomal binding site.
The clindamycin Clinical Pharmacology advises that the clindamycin has to be used only when the infection is been strongly believed or has been proven that it is from the bacteria. This is to prevent any cases of drug resistance and to reduce the effectiveness of the drug.
The drug has to be used with care since it has been reported that it can cause diarrhea as any other antibacterial agents. The diarrhea can range from mild to severe and sometimes the fatal colitis. It is normally because the antibacterial agents alter the flora found in the colon and C difficile overgrows. Since the clindamycin is associated with severe colitis which sometimes can even be fatal, it has to be reserved to treat only some serious infection where the microbial agents are normally inappropriate. This is why also the doctor has to restrain himself from using it to treat other diseases which are not caused by bacteria like upper respiratory tract infection.
The hypertoxin also can contribute to the increase of C difficile which enhances the mortality and morbidity of the medicine. When these infections tend to be fromed refractory to the antimicrobial therapy, they may require that colectomy be used. The doctor has to know your history in taking the Clindamycin since the diarrhea can still occur even after sometime up to 3 months. In case it has been confirmed that the patient is suffering with c difficile, the doctor will have to discontinue the medicine and he will put him on the electrolyte management and appropriate fluid and protein supplementation. Sometimes, the antibiotics can be used to treat the C difficile while the surgical evaluation can be instituted in case it is necessary.
The patient has to be aware that the clindamycin has been developed to treat the infection that has been caused by the bacteria and not virus. The patient has to be warned that he has to continue to take the medicine as it has been directed even if he may begin to feel well in the beginning. When the doses have been skipped or if the doses have been taken up to the end, the effectiveness of the drug can reduce and the bacteria can develop the resistance. It can be hard to treat the same bacteria with the same drug in the future.
The clindamycin Clinical Pharmacology showed that the concentration of the medicine is normally high when the medicine is taken orally. The highest concentration was reached after only 45 minutes and the absorption of the drug if it is taken orally is 90%. The use of the drug with the food has shown that it does not change anything to it’s absorption. The absorption of the drug is easily predictable from a person to another. The drug did not show any evidence for accumulation or for altered metabolism even if the drug has been taken for a long time.
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